Sulfatase 1 (hSulf-1) reverses basic fibroblast growth factor-stimulated signaling and inhibits growth of hepatocellular carcinoma in animal model
作者： Gaoya Xu , Weidan Ji , Yinghan Su , Yang Xu , Yan Yan
关键词:
摘要: The human sulfatase 1 (hSulf-1) gene encodes an endosulfatase that functions to inhibit the heparin-binding growth factor signaling, including basic fibroblast (bFGF)-mediated pathway, by desulfating cell surface heparan sulfate proteoglycans (HSPGs). bFGF could stimulate cycle progression and apoptosis, this biological effect can be reversed hSulf-1. However, molecular mechanisms have not been fully reported. In current study, reactivation of hSulf-1 expression function in hSulf-1-negative hepatocellular carcinoma (HCC) lines HCC xenograft tumors, we found blocked on promotion inhibition apoptosis. bFGF-stimulated activation protein kinase B (AKT) extracellular signal-regulated (ERK) pathways was suppressed hSulf-1, which led a decreased target genes Cyclin D1 Survivin, then finally induced arrest apoptosis cells. Our data suggested may suitable for cancer therapy.
impactjournals.com参考文章(44)
Changqing Su, Hu Liu, Xiaohui Fu, Weidan Ji, Kai Liu, Longlong Bao, Yan Yan, Mengchao Wu, Jiahe Yang, Human sulfatase-1 inhibits the migration and proliferation of SMMC-7721 hepatocellular carcinoma cells by downregulating the growth factor signaling Hepatology Research. ,vol. 43, pp. 516- 525 ,(2013) , 10.1111/J.1872-034X.2012.01080.X
Kodappully Sivaraman Siveen, Kwang Seok Ahn, Tina H Ong, Muthu K Shanmugam, Feng Li, Wei Ney Yap, Alan Prem Kumar, Chee Wai Fong, Vinay Tergaonkar, Kam M Hui, Gautam Sethi, None, γ-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of AKT/mTOR pathway in an orthotopic mouse model Oncotarget. ,vol. 5, pp. 1897- 1911 ,(2014) , 10.18632/ONCOTARGET.1876
Janani Ravi, Amita Sneh, Konstantin Shilo, Mohd W Nasser, Ramesh K Ganju, None, FAAH inhibition enhances anandamide mediated anti-tumorigenic effects in non-small cell lung cancer by downregulating the EGF/EGFR pathway Oncotarget. ,vol. 5, pp. 2475- 2486 ,(2014) , 10.18632/ONCOTARGET.1723
Meng-Shu Tsai, Min-Liang Kuo, Cheng-Chi Chang, Ying-Tai Wu, The effects of exercise training on levels of vascular endothelial growth factor in tumor-bearing mice. Cancer Biomarkers. ,vol. 13, pp. 307- 313 ,(2013) , 10.3233/CBM-130359
Weiguo Wang, Weidan Ji, Huanzhang Hu, Juming Ma, Xiaoya Li, Weiqun Mei, Yang Xu, Huizhen Hu, Yan Yan, Qizhe Song, Zhigang Li, Changqing Su, Survivin promoter-regulated oncolytic adenovirus with Hsp70 gene exerts effective antitumor efficacy in gastric cancer immunotherapy Oncotarget. ,vol. 5, pp. 150- 160 ,(2014) , 10.18632/ONCOTARGET.1430
Guangxun Gao, Liang Chen, Jingxia Li, Dongyun Zhang, Yong Fang, Haishan Huang, Xiequn Chen, Chuanshu Huang, Isorhapontigenin (ISO) inhibited cell transformation by inducing G0/G1 phase arrest via increasing MKP-1 mRNA stability Oncotarget. ,vol. 5, pp. 2664- 2677 ,(2014) , 10.18632/ONCOTARGET.1872
Sagrario Ortega, Marcos Malumbres, Mariano Barbacid, Cyclin D-dependent kinases, INK4 inhibitors and cancer. Biochimica et Biophysica Acta. ,vol. 1602, pp. 73- 87 ,(2002) , 10.1016/S0304-419X(02)00037-9
Do Joong Park, Changhwan Yoon, Nicholas Thomas, Geoffrey Y. Ku, Yelena Y. Janjigian, David P. Kelsen, David H. Ilson, Karyn A. Goodman, Laura H. Tang, Vivian E. Strong, Daniel G. Coit, Sam S. Yoon, Prognostic Significance of Targetable Angiogenic and Growth Factors in Patients Undergoing Resection for Gastric and Gastroesophageal Junction Cancers Annals of Surgical Oncology. ,vol. 21, pp. 1130- 1137 ,(2014) , 10.1245/S10434-013-3429-0
I Abiatari, J Kleeff, J Li, K Felix, M W Buchler, H Friess, Hsulf-1 regulates growth and invasion of pancreatic cancer cells Journal of Clinical Pathology. ,vol. 59, pp. 1052- 1058 ,(2006) , 10.1136/JCP.2005.031716
Christina J. Malavaki, Andreas E. Roussidis, Chrisostomi Gialeli, Dimitris Kletsas, Theodore Tsegenidis, Achileas D. Theocharis, George N. Tzanakakis, Nikos K. Karamanos, Imatinib as a key inhibitor of the platelet-derived growth factor receptor mediated expression of cell surface heparan sulfate proteoglycans and functional properties of breast cancer cells. FEBS Journal. ,vol. 280, pp. 2477- 2489 ,(2013) , 10.1111/FEBS.12163