Critical appraisals of approaches for predictive designs in anticancer drugs.

摘要: The present review provides a critical appraisal of the most important areas in cancer drug research and, ultimately, clinical oncology and therapy, with emphasis on elucidation possible predictive designs for development new anticancer drugs. These assessments encompass well-established drugs congeners which have been employed over years more recent exploratory agents still requiring further rigorous scrutiny environment. mainly include bioreversible redox carriers, boron neutron capture compounds, some mitosis-interactive agents, cell cycle modifiers, biological-response oncogene inhibitors, drug-antibody conjugates, suppression destruction antiangiogenesis antimetastasis apoptosis-promoting gene therapy vaccines.