Demonstration That C-Reactive Protein Decreases eNOS Expression and Bioactivity in Human Aortic Endothelial Cells
作者： Senthil Kumar Venugopal , Sridevi Devaraj , Ivan Yuhanna , Philip Shaul , Ishwarlal Jialal
DOI: 10.1161/01.CIR.0000033116.22237.F9
关键词:
摘要: Background— C-reactive protein (CRP), the prototypic marker of inflammation, has been shown to be an independent predictor cardiovascular events. Endothelial nitric oxide synthase (eNOS) deficiency is a pivotal event in atherogenesis. Methods and Results— We tested effect CRP on eNOS expression bioactivity cultured human aortic endothelial cells (HAECs). decreased mRNA, abundance, enzyme activity HAECs. Furthermore, assayed by cyclic GMP levels was significantly reduced CRP. Preincubation with also increased adhesion monocytes Conclusion— causes direct reduction HAECs, further supporting its role
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J Cermak, NS Key, RR Bach, J Balla, HS Jacob, GM Vercellotti, C-reactive protein induces human peripheral blood monocytes to synthesize tissue factor Blood. ,vol. 82, pp. 513- 520 ,(1993) , 10.1182/BLOOD.V82.2.513.513
Russell P. Tracy, Inflammation markers and coronary heart disease. Current Opinion in Lipidology. ,vol. 10, pp. 435- 441 ,(1999) , 10.1097/00041433-199910000-00008
Joseph Loscalzo, Nitric Oxide and Vascular Disease New England Journal of Medicine. ,vol. 333, pp. 251- 253 ,(1995) , 10.1056/NEJM199507273330410
Sridevi Devaraj, Ishwarlal Jialal, α-Tocopherol Decreases Interleukin-1β Release From Activated Human Monocytes by Inhibition of 5-Lipoxygenase Arteriosclerosis, Thrombosis, and Vascular Biology. ,vol. 19, pp. 1125- 1133 ,(1999) , 10.1161/01.ATV.19.4.1125
Vincenzo Pasceri, Jed Chang, James T. Willerson, Edward T. H. Yeh, Modulation of C-Reactive Protein–Mediated Monocyte Chemoattractant Protein-1 Induction in Human Endothelial Cells by Anti-Atherosclerosis Drugs Circulation. ,vol. 103, pp. 2531- 2534 ,(2001) , 10.1161/01.CIR.103.21.2531
Philip W. Shaul, Eric J. Smart, Lisa J. Robinson, Zohre German, Ivan S. Yuhanna, Yunshu Ying, Richard G. W. Anderson, Thomas Michel, Acylation Targets Endothelial Nitric-oxide Synthase to Plasmalemmal Caveolae Journal of Biological Chemistry. ,vol. 271, pp. 6518- 6522 ,(1996) , 10.1074/JBC.271.11.6518
Subodh Verma, Shu-Hong Li, Mitesh V. Badiwala, Richard D. Weisel, Paul W.M. Fedak, Ren-Ke Li, Bikramjit Dhillon, Donald A.G. Mickle, Endothelin Antagonism and Interleukin-6 Inhibition Attenuate the Proatherogenic Effects of C-Reactive Protein Circulation. ,vol. 105, pp. 1890- 1896 ,(2002) , 10.1161/01.CIR.0000015126.83143.B4
Rainer H. Böger, Stefanie M. Bode-Böger, Jürgen C. Frölich, The l-arginine—nitric oxide pathway: role in atherosclerosis and therapeutic implications Atherosclerosis. ,vol. 127, pp. 1- 11 ,(1996) , 10.1016/S0021-9150(96)05953-9
Stephan Fichtlscherer, Gunter Rosenberger, Dirk H. Walter, Susanne Breuer, Stefanie Dimmeler, Andreas M. Zeiher, Elevated C-Reactive Protein Levels and Impaired Endothelial Vasoreactivity in Patients With Coronary Artery Disease Circulation. ,vol. 102, pp. 1000- 1006 ,(2000) , 10.1161/01.CIR.102.9.1000
David A Morrow, Nader Rifai, Elliott M Antman, Debra L Weiner, Carolyn H McCabe, Christopher P Cannon, Eugene Braunwald, None, C-Reactive Protein Is a Potent Predictor of Mortality Independently of and in Combination With Troponin T in Acute Coronary Syndromes: A TIMI 11A Substudy Journal of the American College of Cardiology. ,vol. 31, pp. 1460- 1465 ,(1998) , 10.1016/S0735-1097(98)00136-3