Predictors of 25-hydroxyvitamin D levels in HIV-infected patients in Hawai'i.

摘要: HIV-infected individuals are at increased risk for several metabolic diseases, including low 25-hydroxyvitamin D [25(OH)D]. Data on the prevalence and factors 25(OH)D in HIV patients living tropics is scarce. Patients ≥ 40 years old stable antiretroviral therapy were enrolled from March 2009 to July 2011 Hawai‘i (latitude 21° North). Chemiluminescent immunoassay (DiaSorin) was used determine plasma levels. grouped by whether collected summer (May 1 – September 30) or winter (October April 30). Of 158 enrolled, 88 (56%) 70 (44%) summer, respectively. There 57.6% Caucasians 88% men. Over-all median (quartile1, quartile3) age 51 (46, 57) 32.4 (24.0, 41.0) ng/ml. Forty-three percent (n=68) had 25(OH)D<30.0 Median levels 29.6 (22.0, 38.0) ng/ml 36.9 (25.0, 44.5) (P = .01). body mass index (BMI) of significantly higher .03). By simple linear regression, log-transformed associated with visit (β −.0737, P .01), ethnicity (Caucasian versus non-Caucasian, β .1194, < BMI −.0111, .01) current use zidovudine −.1233, In multiple only Caucasian .1004, −.0078, .02) retained statistical significance. Seasonal variation observed but significance not preserved final multivariate model. Ethnicity better predictors than season tropics.