Effets de l'atropine sur la réponse adrénergique à l'exercice en hypoxie d'altitude (4 350 m)

作者: JP Richalet , C Rathat , A Kéromès , P Larmignat

DOI: 10.1016/S0765-1597(05)80209-6

关键词:

摘要: Resume La contribution du systeme parasympathique aux modifications de l'activite chronotrope cardiaque a l'exercice induites par l'hypoxie d'altitude ete etudiee chez 10 sujets sains natifs basse altitude. Un exercice sous-maximal (60% la puissance maximale aerobie) minutes pratique apres ou non-injection intraveineuse d'atropine (1 mg) en normoxie et hypoxie (le 2 e le 3 jour 4 350 m d'altitude). Une analyse variance montre que l'effet l'atropine sur frequence est meme hypoxie: tonus vagal s'estompe facon equivalente hypoxie. mesure des concentrations catecholamines circulantes s'accompagne d'une augmentation adrenergique, mais l'activation adrenergique suscitee n'est modifiee ni l'atropine. Au total, role dans lors d'un pas modifie aigue.

参考文章(24)
J. T. Maher, J. C. Deniiston, D. L. Wolfe, A. Cymerman, Mechanism of the attenuated cardiac response to beta-adrenergic stimulation in chronic hypoxia Journal of Applied Physiology. ,vol. 44, pp. 647- 651 ,(1978) , 10.1152/JAPPL.1978.44.5.647
K Klausen, S Robinson, E D Micahel, L G Myhre, Effect of high altitude on maximal working capacity. Journal of Applied Physiology. ,vol. 21, pp. 1191- 1194 ,(1966) , 10.1152/JAPPL.1966.21.4.1191
L H Hartley, J A Vogel, J C Cruz, Reduction of maximal exercise heart rate at altitude and its reversal with atropine. Journal of Applied Physiology. ,vol. 36, pp. 362- 365 ,(1974) , 10.1152/JAPPL.1974.36.3.362
FRANCOIS PERONNET, JEAN CLEROUX, HELENE PERRAULT, GUY THIBAULT, DANIEL COUSINEAU, JACQUES de CHAMPLAIN, JEAN-CLAUDE GUILLAND, JACQUES KLEPPING, Plasma norepinephrine, epinephrine, and dopamine beta-hydroxylase activity during exercise in man. Medicine and Science in Sports and Exercise. ,vol. 17, pp. 683- 688 ,(1985) , 10.1249/00005768-198512000-00011
S C Hammill, W W Wagner, L P Latham, W W Frost, J V Weil, Autonomic cardiovascular control during hypoxia in the dog. Circulation Research. ,vol. 44, pp. 569- 575 ,(1979) , 10.1161/01.RES.44.4.569
J.-P. Richalet, H. Mehdioui, C. Rathat, P. Vignon, A. Keromes, J.-P. Herry, C. Sabatier, M. Tanche, F. Lhoste, Acute hypoxia decreases cardiac response to catecholamines in exercising humans International Journal of Sports Medicine. ,vol. 9, pp. 157- 162 ,(1988) , 10.1055/S-2007-1024997
P BOUISSOU, G DEFER, C Y GUEZENNEC, P Y ESTRADE, B SERRURIER, Metabolic and blood catecholamine responses to exercise during alkalosis. Medicine and Science in Sports and Exercise. ,vol. 20, pp. 228- 232 ,(1988) , 10.1249/00005768-198806000-00003
P. Pilardeau, J. -P. Richalet, P. Bouissou, J. Vaysse, P. Larmignat, A. Boom, Saliva flow and composition in humans exposed to acute altitude hypoxia. European Journal of Applied Physiology. ,vol. 59, pp. 450- 453 ,(1990) , 10.1007/BF02388627
P. Bouissou, F. Péronnet, G. Brisson, R. Hélie, M. Ledoux, Metabolic and endocrine responses to graded exercise under acute hypoxia. European Journal of Applied Physiology. ,vol. 55, pp. 290- 294 ,(1986) , 10.1007/BF02343801
J Stenberg, B Ekblom, R Messin, Hemodynamic response to work at simulated altitude, 4,000 m. Journal of Applied Physiology. ,vol. 21, pp. 1589- 1594 ,(1966) , 10.1152/JAPPL.1966.21.5.1589