Activity assays for extracellular signal-regulated kinase 5.
作者： Kazuhiro Nakamura , Gary L. Johnson
DOI: 10.1007/978-1-60761-795-2_5
关键词:
摘要: Extracellular signal-regulated kinase 5 (ERK5) is also known as big MAPK (BMK1) or MAPK7. ERK5 115 kDa in mass and therefore larger than the other MAPKs such ERK1/2, JNK, p38. Like MAPKs, ubiquitously expressed mammalian cells part of a three cascade involving (MEK5) (primarily MEKK2 MEKK3). important for proliferative responses to growth factors like epidermal factor stress hyperosmolarity. Upon stimulation, rapidly translocates nucleus control transcription. critical maintenance vascular integrity endothelial cell survival. In this chapter, we define methods used measure activation using different biochemical cell-based assays.
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