Prognostic outcomes and decision-making for local-regional therapy after neoadjuvant chemotherapy: Pretreatment clinical staging or posttreatment pathologic staging?

摘要: Presurgical chemotherapy is increasingly implemented as it improves breast conservation rates and may reveal novel information about therapeutic response. However, neoadjuvant therapy raises questions prognosis decision making for adjuvant local-regional therapy. Current prognostic treatment planning typically based on American Joint Committee Cancer staging patients treated with This not readily applicable to chemotherapy, however, neither pretreatment clinical data nor post-treatment pathologic alone accurately reflect disease status. review summarizes the implementation of a new system receiving combines factors biologic markers refine assessment Controversies related sentinel lymph node biopsy, postmastectomy radiation therapy, are also discussed.