Omniphilic Polysaccharide-Based Nanocarriers for Modular Molecular Delivery in a Broad Range of Biosystems

摘要: Self-adjusting omniphilic nanocarriers (OPNs) with a multisolvent aptitude were prepared via Schiff base reaction between chitosan, natural polysaccharide, and bioactive aldehydes. Experimental studies supported by atomistic molecular dynamics simulations revealed these OPNs can encapsulate insoluble cargo, transport them in aqueous or lipid environments, deliver through cross-phase barriers. N-imine dynamic covalent bonds have been incorporated to endow the pH responsiveness, also allowing amplification of their bioactivity, as demonstrated vitro ability delay fungal proliferation wheat grains. The reported hold remarkable potential biocompatible for effective delivery active agents agriculture, medicine, cosmetics.