Jet Cutting Technique for the Production of Chitosan Aerogel Microparticles Loaded with Vancomycin

摘要: Biopolymer-based aerogels can be obtained by supercritical drying of wet gels and endowed with outstanding properties for biomedical applications. Namely, polysaccharide-based in the form microparticles are special interest wound treatment also loaded bioactive agents to improve healing process. However, production precursor gel may limited viscosity polysaccharide initial solution. The jet cutting technique is regarded as a suitable processing overcome this problem. In work, technological combination was assessed produce chitosan aerogel vancomycin HCl (antimicrobial agent) purposes. resulting formulation evaluated terms morphology, textural properties, drug loading, release profile. Aerogels were tested application exudate sorption capacity, antimicrobial activity, hemocompatibility, cytocompatibility. Overall, had excellent absorbed high amounts exudate, controlled HCl, providing sustained activity.