MIG-6 and SPRY2 in the Regulation of Receptor Tyrosine Kinase Signaling: Balancing Act via Negative Feedback Loops

摘要: Tumor suppressor genes (TSGs) function in concert with diverse parts of the cellular machi‐ nery and integrate signaling networks a cell [1]. TSGs act to safeguard networks, fine-tune outputs, maintain tissue homeostasis. The loss tumor sup‐ pressor activity or inactivation TSG is often due genetic alterations such as loss-offunction mutation deletion gene; alternatively, epigenetic silencing can result from methylation histone modification TSG’s promoter regulatory elements [1-3]. Cells significant reduction particular suppressor’s are prone develop neoplasia tissues/organs where expressed [1, 2].