Comparative Susceptibility of Chickens and Turkeys to Avian Influenza A H7N2 Virus Infection and Protective Efficacy of a Commercial Avian Influenza H7N2 Virus Vaccine

作者: Terrence M. Tumpey , Darrell R. Kapczynski , David E. Swayne

DOI: 10.1637/7103

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摘要: Abstract During the spring of 2002, a low pathogenic avian influenza (LPAI) A (H7N2) virus caused major outbreak among commercial poultry in Virginia and adjacent states. The primarily affected turkey flocks, causing respiratory distress decreased egg production. Experimentally, turkeys were more susceptible than chickens to H7N2 infection, with 50% bird infectious dose titers equal 100.8 102.8–3.2, respectively. Comparison shedding from cloaca oropharynx demonstrated that recent isolates readily isolated upper tract but rarely gastrointestinal tract. raised concerns regarding availability vaccines could be used for prevention control this poultry. We sought determine if an existing (AI) vaccine prepared 1997 seed stock provide protection against 2002 LPAI (A/turkey/Virginia/15...

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