Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database

摘要: The past decade has witnessed hundreds of reports declaring or refuting genetic association with putative Alzheimer disease susceptibility genes. This wealth information become increasingly difficult to follow, much less interpret. We have created a publicly available, continuously updated database that comprehensively catalogs all studies in the field (http://www.alzgene.org). performed systematic meta-analyses for each polymorphism available genotype data at least three case-control samples. In addition identifying epsilon4 allele APOE and related effects, we pinpointed over dozen potential genes (ACE, CHRNB2, CST3, ESR1, GAPDHS, IDE, MTHFR, NCSTN, PRNP, PSEN1, TF, TFAM TNF) statistically significant allelic summary odds ratios (ranging from 1.11-1.38 risk alleles 0.92-0.67 protective alleles). Our provides powerful tool deciphering genetics disease, it serves as model tracking most viable gene candidates other genetically complex diseases.