The Potential of Targeting Splicing for Cancer Therapy

摘要: Many molecules currently used to treat cancer patients target proteins encoded by transcripts that are alternatively spliced. As a consequence, the treatment may simultaneously block isoforms with different and sometimes opposing biological activity, thus reducing its efficacy. Recent studies highlight role of splicing regulation in progression importance machinery as therapeutic target. In reviewing this emerging field biology, we describe very exciting novel findings illustrate range scenarios which alternative can contribute all hallmarks, from avoidance apoptosis angiogenesis, invasion acquired resistance drug therapy. Finally, address cancer-selective approaches being developed interfere modulate decisions.