摘要: In biological processes after energy deposition of radiation in cells, DNA damage occurs at first to produce chromosomal breaks and then appear many cell responses. Reproductive interphase death causes inactivation cancer tissue. Traditional target theory linear quadratic model are used explain mechanism treatment prediction. There factors modify the efficiency radiobiological effects such as oxygen other chemical substances well physical distribution radiation. For high-LET radiations, relative effectiveness is most important factor on therapy enhancement ratio.
springer.com
sci-hub.st 参考文章(18)
Michael C Joiner, Albert J van der Kogel, Basic Clinical Radiobiology ,(2009)
O. Kranenburg, A. J. van der Eb, A. Zantema, Cyclin D1 is an essential mediator of apoptotic neuronal cell death. The EMBO Journal. ,vol. 15, pp. 46- 54 ,(1996) , 10.1002/J.1460-2075.1996.TB00332.X
Y. Furusawa, K. Fukutsu, M. Aoki, H. Itsukaichi, K. Eguchi-Kasai, H. Ohara, F. Yatagai, T. Kanai, K. Ando, Inactivation of Aerobic and Hypoxic Cells from Three Different Cell Lines by Accelerated 3He-, 12C- and 20Ne-Ion Beams Radiation Research. ,vol. 154, pp. 485- 496 ,(2000) , 10.1667/0033-7587(2000)154[0485:IOAAHC]2.0.CO;2
Toyozo Terasima, L.J. Tolmach, Variations in Several Responses of HeLa Cells to X-Irradiation during the Division Cycle Biophysical Journal. ,vol. 3, pp. 11- 33 ,(1963) , 10.1016/S0006-3495(63)86801-0
Olivier Stevaux, Nicholas J Dyson, A revised picture of the E2F transcriptional network and RB function. Current Opinion in Cell Biology. ,vol. 14, pp. 684- 691 ,(2002) , 10.1016/S0955-0674(02)00388-5
Tatiana Wenzl, Jan J Wilkens, Modelling of the oxygen enhancement ratio for ion beam radiation therapy Physics in Medicine and Biology. ,vol. 56, pp. 3251- 3268 ,(2011) , 10.1088/0031-9155/56/11/006
H P Leenhouts, K H Chadwick, The influence of dose rate on the dose-effect relationship Journal of Radiological Protection. ,vol. 10, pp. 95- 102 ,(1990) , 10.1088/0952-4746/10/2/002
Yukihiro Furusawa, Zheng-Li Wei, Hiroaki Sakurai, Yoshiaki Tabuchi, Peng Li, Qing-Li Zhao, Takaharu Nomura, Ikuo Saiki, Takashi Kondo, TGF-β-Activated Kinase 1 Promotes Cell Cycle Arrest and Cell Survival of X-Ray Irradiated HeLa Cells Dependent on p21 Induction but Independent of NF-κB, p38 MAPK and ERK Phosphorylations Radiation Research. ,vol. 177, pp. 766- 774 ,(2012) , 10.1667/RR2792.1
K Fukuda, C Sakakura, K Miyagawa, Y Kuriu, S Kin, Y Nakase, A Hagiwara, S Mitsufuji, Y Okazaki, Y Hayashizaki, H Yamagishi, Differential gene expression profiles of radioresistant oesophageal cancer cell lines established by continuous fractionated irradiation. British Journal of Cancer. ,vol. 91, pp. 1543- 1550 ,(2004) , 10.1038/SJ.BJC.6602187
T. Terasima, L. J. Tolmach, X-Ray Sensitivity and DNA Synthesis in Synchronous Populations of HeLa Cells Science. ,vol. 140, pp. 490- 492 ,(1963) , 10.1126/SCIENCE.140.3566.490