Combined salvage therapies for recurrent glioblastoma multiforme: evaluation of an interdisciplinary treatment algorithm

摘要: Glioblastoma multiforme patients presenting with recurrence following multimodality therapy have limited palliative treatment options when the major modalities of including surgery, radiochemotherapy and adjuvant chemotherapy been exhausted. The authors introduce a clinical radiological indication-solving algorithm provide outcome rates glioblastoma cohort. Sixty six consecutive adult recurrent who underwent combined scheme salvage treatments consisting reoperation, high dose rate (HDR) brachytherapy were included in this prospective study compared to historical control group 24 treated intensive temozolomide as only modality. Median follow-up was 32 months (range 28-36 months). survival 9 for entire cohort after can be translated into 3-month improvement alone (P = 0.043). Toxicity adverse events HDR quite favourable temomozolomide treatment. Our experience suggests that plan appears both feasible effective considered selected affected by grade gliomas. authors' may assist providing best possible difficult population.