The anti-inflammatory activity of L-menthol compared to mint oil in human monocytes in vitro: a novel perspective for its therapeutic use in inflammatory diseases.

摘要: The anti-inflammatory efficacy of monoterpenes is still unknown. In order to evaluate the potential role L-menthol and mint oil as an drug, preclinical in vitro-investigations were performed using LPS-stimulated monocytes from healthy volunteers. Arachidonic acid metabolism was assessed by measuring LTB subset4 PGE subset2 indicators for both lipoxygenase cyclooxygenase pathways respectively. addition, effects two terpenes on IL-1beta production analysed. - significantly suppressed each three inflammation mediators vitro. decreased -64.4 +/- 10%, -56.6 8%, -64.2 7% respectively at concentrations within presumed therapeutic range about 10 superset-7 g/ml. contrast, had a bimodal effect production: lower superset-10 superset-8 g/ml increased up 6-fold compared baseline but approximately 50%. Mint similar its main constituent, L-menthol, although degree suppression comparison smaller concentrations. Paraffin oil, which served solvent, did not affect arachidonic production. These results obtained with human suggest preferable therapeutically relevant supplied enteric coated capsules. Therefore, clinical trials investigating treatment chronic inflammatory disorders such bronchial asthma, colitis allergic rhinitis seem worthwhile.