Validation of a new strength measurement device for amyotrophic lateral sclerosis clinical trials

摘要: Introduction: Strength measures with reduced variability and higher sensitivity could improve efficiency in clinical trials of amyotrophic lateral sclerosis (ALS). The Accurate Test Limb Isometric Strength (ATLIS) was developed to precisely conveniently measure force 12 muscle groups. In this study we evaluate the reliability validity ATLIS testing protocol. Methods: Twenty healthy adults 10 patients ALS were tested twice by same or different evaluators determine test–retest interrater reliability. Twenty examined using a well-validated strength protocol (TQNE) assess criterion-based validity. Results: Mean absolute variation between tests 8.6%, intraclass correlation coefficients for each group high (range 0.82–0.99). Pearson coefficient mean TQNE scores 0.90. A subject survey demonstrated user acceptance ATLIS. Conclusions: ATLIS is convenient evaluators, produces precise measurements, easily moved examining rooms. Muscle Nerve 45: 81–85, 2012