Diffusion-Weighted Imaging Characteristics of Primary Central Nervous System Germinoma with Histopathologic Correlation

摘要: Rationale and Objectives The aim of this study was to quantify, using diffusion-weighted magnetic resonance imaging, the microscopic rate water diffusion in pure germinoma determine whether or not apparent coefficient (ADC) values correlated with different histologic components. Materials Methods A retrospective analysis echoplanar images conducted on 10 patients 11 lesions. All were obtained 1.5-T magnets a b value 1000 s/mm2. Regions interest drawn separately within solid cystic necrotic components each germinoma, as well normal gray white matter respective cases, calculate ADCs. characteristics germinomas assessed mean normalized ADC values. Histologic samples from all cases blindly reviewed then Results Data are expressed ± standard error. Evaluation revealed that 36% (4 11) had predominantly restricted (ADCsolid, 694.71 × 10−6 ± 74.54 × 10−6 s/mm2; ratio, 0.84 ± 0.07) compared brain. majority (55% [6 11]) 947.64 × 10−6 ± 54.38 × 10−6 1.14 ± 0.10). Only 9% (1 increased 1172.30 × 10−6 ± 48.52 × 10−6 1.67 ± 0.16). ratio 2.55 ± 0.25. There no significant correlation between germinomas. Conclusions vast demonstrated (36%) (55%) diffusion.