Cytotoxic Constituents of Baccharis gaudichaudiana

摘要: Three new labdane diterpenes, gaudichaudols A-C [1-3], a clerodane diterpenoid, gaudichaudone [4], and the known clerodane, articulin acetate [5] have been isolated from aerial parts of Baccharis gaudichaudiana, together with compounds, apigenin, hispidulin, spathulenol, ursolic acid. Through application 1D- 2D nmr spectroscopy, structures diterpenoids [1-4] were, in turn; elucidated as 15,16,18,19-tetrahydroxylabd-5-ene, 15-O-acetyl-16,18,19-trihydroxylabd-5-ene, 16-O-p-trans-coumaroyl-15,18,19-trihydroxylabd-5-ene, 2 beta-hydroxy-15,16-epoxycleroda-1(10),15,16-trien-18,19-olide++ +. The compounds were evaluated P-388 lymphocytic leukemia cells well battery human cancer cell lines. Among diterpenoids, gaudichaudol C [3], exhibited significant cytotoxic activity against certain cells.