Impaired collateral vessel development in diabetes: potential cellular mechanisms and therapeutic implications.

摘要: The formation of coronary collateral vessels is a compensatory mechanism secondary to repetitive or chronic myocardial ischemia. During the past three decades functional and prognostic benefit such has been established. There are large interindividual differences in number extent that may be explained by anatomic situation individual capacity develop vessels. Diabetes mellitus recently identified as one first negative predictors vessel formation. Novel molecular approaches have helped improve our understanding process recent years. Besides true angiogenesis, i.e. new capillaries out preexisting ones, circulation largely based on growth arterioles (collateral anastomoses) named arteriogenesis. One important feature arteriogenesis infiltration monocytes into growing vessel. Our group shows ability migrate towards gradient VEGF-A severely impaired diabetic individuals, this response seems signal transduction defect within monocyte. In review pathophysiology diabetes-related monocyte dysfunction potential role discussed.