Chapter 26. Regulation of Apoptosis by Members of the ICE Family and the Bcl-2 Family

摘要: Publisher Summary A recognition of the various intracellular proteins involved in induction and execution apoptosis has occurred recently. The aggregating factors utilize death domain to transfer a signal from stimulated receptor. It seems likely that domains can induce conformational changes as described for role mastoparan activation G-proteins. Members an expanding family cellular cysteine proteases, interleukin-1β converting enzyme (ICE) family, play key roles initiation programmed cell caused by diverse assortment stimulators. Activation ICE proteases is partially controlled B-cell lymphoma/leukemia-2 (Bcl-2) family. Bcl-2 aggregate means their BH1, BH2, BH3 domains, but it unclear how these directly control proteases. clear only certain pathways are affected members; Fas-induced apoptosis, example, not inhibited members, although such inducers serum deprivation, irradiation, staurosporine treatment inhibited. Of viral homologs, E1B19K, generally appear have wider spectrum inhibition than do mammalian members transfection systems. Other inhibitors CrmA p35, be direct executioner These function downstream emerging third group contain enable transduction pro-apoptotic receptors This chapter discusses structure, activity, interaction protein families, following apoptotic stimulation