Putting an 'End' to HIV mRNAs: capping and polyadenylation as potential therapeutic targets

摘要: Like most cellular mRNAs, the 5′ end of HIV mRNAs is capped and 3′ matured by process polyadenylation. There are, however, several rather unique interesting aspects these post-transcriptional processes on transcripts. Capping highly structured influenced viral TAT protein a population contains trimethyl-G cap reminiscent U snRNAs involved in splicing. polyadenylation involves active repression promoter-proximal signal, auxiliary upstream regulatory elements moonlighting factors that have additional impacts biology outside constraints classical mRNA 3’ formation. This review describes novelties gene expression as well their implications possible targets for therapeutic intervention.