Unique amyloid protein subunit common to different types of amyloid fibril.

作者: G. HUSBY , J. B. NATVIG , T. E. MICHAELSEN , K. SLETTEN , H. HÖST

DOI: 10.1038/244362A0

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摘要: IT has been shown by Glenner et al.1 that certain amyloid fibrils, chiefly derived from primary amyloidosis or associated with myelomatosis, consist of immunoglobulin chains their fragments. The principal component these fibrils seems to be the variable part monoclonal κ λ light (Bence-Jones proteins). In addition, a “non-immunoglobulin” fibril protein molecular weight 85,000, named us AS (amyloid subunit), which comprises an essential some secondary detected Benditt al.2 and other groups3–5. is found in amyloid, chronic inflammations, suggested fragment hitherto unknown larger protein4. Except for detection chain material connected type6,7, no chemical link between (“light chain”) (“non-immunoglobulin”) classes substances established. On contrary, question raised whether there are two completely different amyloid8.

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