TMSCl Promoted Direct sp3C-H Alkenylation to Construct (E)-2-Styryl-tetrahydrobenzo[d]thiazoles

摘要: A high-efficient and stereo-specific approach for the preparation of biologically important (E)-2-styryl-tetrahydrobenzo[d]thiazoles has been developed via TMSCl promoted direct sp3 C-H alkenylation 2-methyl-5,6-dihydrobenzo[d]thiazol-7(4H)-one under metal-free conditions. Seventeen target compounds were synthesized in excellent yields 82% –98% optimal conditions 300 mol% at 110°C 2 h, their chemical structures elucidated by IR, NMR, ESI-MS, elemental analyses X-ray crystallography analysis. plausible mechanism was also proposed, this method provided a good functional group conversion substrates.