Pharmaceutical compositions for high-capacity targeted delivery

摘要: Provided herein are aptamers and pharmaceutical compositions comprising the same. In some embodiments, aptamer selectively binds a protein of interest such as an extracellular receptor (e.g., cancer cell protein, which may be differentially expressed in embodiments). is directly linked by covalent bonding via geminal diamine linkage) to from 2 10 toxin compounds. Also provided method selecting that specifically interest, wherein embodiments comprises at least one binding site for or more active primer regions flanking variable region pool contains 1 mismatches with respect said forward reverse primer.