Bence Jones Proteins and Light Chains of Immunoglobulins XIV.
作者： A. SOLOMON
DOI: 10.1111/J.1365-3083.1976.TB03018.X
关键词:
摘要: The region on the light chain molecule responsible for expression of kappa and lambda antigenic determinants was determined by comparative immunochemical analyses intact Bence Jones proteins naturally occurring or enzymatically derived fragments that lacked extensive portions V part C region. reactivity these with numerous antisera having specificity light-chain indicated essentiality polypeptide determinants. conformational dependency also evidenced denaturation-renaturation studies chains. domain, interdomain 'switch' contribute to antigenicity certain isotypic allotypic specificities.
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