Therapeutic agents and methods for cardiovascular disease

摘要: The present invention provides methods and agents for treating subjects who have or are at risk of developing having cardiovascular disease. Such inhibit binding myeloperoxidase (MPO) to a molecule comprising the MPO site apolipoprotein A-1 (apoA-1) include peptide fragment apoA-1 least 4 contiguous amino acids in SEQ ID. NO: 2, modified form apo-1 one more D acids, retro-inverso fragment, an organo-mimetic peptide-mimetic apoA1 nucleic acid encoding apo fragment. also identifying screening test CVD. method comprises incubating with under conditions which permit determining whether such binding.