Streptonigrin. 1. Structure-activity relationships among simple bicyclic analogs. Rate dependence of DNA degradation on quinone reduction potential

摘要: A series of simple aza and diaza bicyclic quinones related to the AB ring system streptonigrin (1) have been synthesized tested in vitro for their ability degrade DNA under conditions similar those used with parent drug. The results obtained from a study 22 indicate that there is quantitative linear relationship between reduction potentials rate at which they identical vitro. Almost all synthetic substances were superior 1 DNA-degrading ability.