Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2.

摘要: The maintenance of peripheral naive T lymphocytes in humans is dependent on their homeostatic division, not continuing emigration from the thymus, which undergoes involution with age. However, postthymic cells still poorly understood. Previously we reported that recent thymic emigrants (RTEs) are contained CD31+CD25- as defined by levels signal joint cell receptor rearrangement excision circles (sjTRECs). Here, differential gene expression analysis followed protein and functional studies, define having divided least since express complement receptors (CR1 CR2) known to bind C3b- C3d-decorated microbial products and, following activation, produce IL-8 (CXCL8), a major chemoattractant for neutrophils bacterial defense. We also observed an IL-8-producing memory subpopulation coexpressing CR1 CR2 signature resembling RTEs. functions remain be determined, but note Epstein-Barr virus, cause lymphomas candidate environmental factor autoimmune disease.