PAK1-mediated MORC2 phosphorylation promotes gastric tumorigenesis

摘要: // Guiling Wang 1 , Yanyan Song Tong Liu Chunyu Qing Zhang Furong Xinze Cai Zhifeng Miao 2 Hongde Xu Huimian Cao Feng Li Department of Cell Biology, Key Laboratory Ministry Public Health, and Medical Education, China University, Shenyang, Surgical Oncology General Surgery, First Hospital Correspondence to: Li, e-mail: fli@mail.cmu.edu.cn Wang, wanggl@mail.cmu.edu.cn Keywords: MORC2, phosphorylation, P21-activated kinase 1(PAK1), gastric cancer Received: November 23, 2014      Accepted: January 2015      Published: March 21, 2015 ABSTRACT To date, microrchidia (MORC) family CW-type zinc-finger (MORC2), has been found to be involved in p21-activated kinase1 (PAK1) pathway maintain genomic integrity. Here, we explore its novel role cancer. We demonstrate that PAK1-mediated MORC2 phosphorylation promotes cell cycle progression, defective MORC2-S677A results attenuated proliferation tumorigenicity cells, which is significantly enhanced overexpression phospho-mimic MORC2-S677E form, suggesting the importance tumorigenesis. More importantly, correlates positively with PAK1 expression clinical Furthermore, high appear associated poor prognosis Collectively, these findings revealed a function promoting vitro tumorigenesis vivo blocking might potential therapeutic strategy for