Validation of nonrigid image registration using finite-element methods: application to breast MR images

摘要: Presents a novel method for validation of nonrigid medical image registration. This is based on the simulation physically plausible, biomechanical tissue deformations using finite-element methods. Applying range displacements to models different patient anatomies generates model solutions which simulate gold standard deformations. From these solutions, deformed images are generated with typical those likely occur in vivo. The registration accuracy respect simulations quantified by co-registering original and comparing recovered voxel biomechanically simulated ones. functionality demonstrated previously described technique free-form B-splines normalized mutual information as similarity measure, an application contrast-enhanced magnetic resonance mammography pairs. exemplar shown be subvoxel average this particular application. presented here important step toward more generic plausible quantification motion recovery It will provide basis improving techniques diversity applications, such intrasubject deformation or correction brain, liver heart.