Assessment of the Genotoxic and Antioxidant Activities of Several Vegetables, Spices and Herbs in Combination with Cyclophosphamide and 4-Nitroquinoline n-Oxide in Drosophila Melanogaster

摘要: It has been demonstrated that the juices from several vegetables, spices and herbs protect against certain carcinogens. The antioxidant capacity of vegetables documented. aims present study were to evaluate genotoxicity celery, coriander, epazote, parsley watercress using Somatic Mutation Recombination Test (SMART) on wings Drosophila melanogaster Standard (ST) High Bioactivation (HB) crosses with regular high levels metabolizing cytochrome P450 enzymes, respectively. protective effects extracts 4-Nitroquinoline n-Oxide (4NQO) 4NQO, an oxidant compound, Cyclophosphamide (CP), alkylating agent, evaluated. Both promutagens employed alone as positive controls in combination extracts. majority non-genotoxic, although results observed. Parsley induced spots at all concentrations assayed ST cross lowest concentration HB cross. Watercress, coriander epazote produced some significant both crosses. CP highest extract exhibited a potentiation-synergistic effect while inhibition-antagonic 4NQO. In addition, radical-scavenging activities investigated colorimetrical DPPH oxidative assay. radical scavenging activity order lower was > celery epazote.