Visualization of tegument-capsid interactions and DNA in intact herpes simplex virus type 1 virions.
作者： Z. Hong Zhou , Dong Hua Chen , Joanita Jakana , Frazer J. Rixon , Wah Chiu
DOI: 10.1128/JVI.73.4.3210-3218.1999
关键词:
摘要: Herpes simplex virus type 1 virions were examined by electron cryomicroscopy, allowing the three-dimensional structure of infectious particle to be visualized for first time. The capsid shell is identical that B-capsids purified from host cell nucleus, with exception penton channel, which closed. double-stranded DNA genome organized as regularly spaced ( approximately 26 A) concentric layers inside capsid. This pattern suggests a spool model packaging, similar some bacteriophages. bulk tegument not icosahedrally ordered. However, small portion appears filamentous structures around pentons, interacting extensively Their locations and interactions suggest possible roles proteins in regulating transport through channel binding cellular during viral infection.
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