The use of urinary enzyme measurements to detect renal damage caused by nephrotoxic compounds.

摘要: Abstract Several known and suspected nephrotoxic agents were administered to male Wistar rats the excretion rates of 4 enzymes located largely in specific regions cell measured. The lactate dehydrogenase alkaline phosphatase urine was considerably increased severity renal damage appeared be related enzyme activity present urine. acid glutamate usually within normal limits or only slightly raised. 4-Aminocatechol, an abnormal metabolite phenacetin causing kidney damage, gave results for suggesting absence lesions rat. value urinary measurements detect acute by toxic compounds identify primary lesion is discussed.