Matrix metalloproteinases and their inhibition in periodontal treatment.

摘要: Matrix metalloproteinases (MMPs), produced by both infiltrating and resident cells of the periodontium, play a role in physiologic (e.g., tooth eruption) pathologic periodontitis) events. The evidence for MMPs periodontal destruction has accumulated over three half decades, it is now recognized that an imbalance between activated their endogenous inhibitors leads to breakdown extracellular matrix during periodontitis. This understanding stimulated search number synthetic could be used as potential therapeutic agents. Tetracycline analogues, proteinase inhibitors, are currently closer being clinically than any other agents therapy. Other MMP such Batimastat (British Bio-technology, Oxford, UK), tested inhibition cancer metastasis diseases. Multiple mechanisms tetracycline analogues have been proposed. nonantimicrobial chemically modified tetracyclines potent MMPs, preventing collagen alveolar bone loss animal models In addition, low doses commercially available semisynthetic doxycycline, human clinical trails reduce activity gingival crevicular fluid tissues, with resultant reduction pocket depth attachment loss. Of particular interest, research on properties generated new approaches variety medical disorders characterized excess activity.