Integrative therapy decreases the risk of lupus nephritis in patients with systemic lupus erythematosus: A population-based retrospective cohort study.

摘要: Ethnopharmacological relevance Evidence on alleviating the risk of lupus nephritis by integrative therapy with conventional medicine (CM) and herbal (HM) had not been addressed. Aim study We investigated effect associated a retrospective Systemic Lupus Erythematosus (SLE) cohort from Taiwan National Health Insurance Research Database (NHIRD). Materials methods SLE patients catastrophic illness certificate (CIC) were retrospectively enrolled SLE NHIRD between 1997 2011. The divided into an (IM: integrated CM plus HM) non-IM (CM only) group 1:1 propensity score matching. Cox proportional regression model Kaplan-Meier method conducted to estimate hazard ratio (HR) for in cohort. Results Among 16,645 newly diagnosed holding CIC (SLE/CIC), 1933 received HM 1571 no treatment. After matching, there 273 nephritis-120 IM 153 group. adjusted HR (0.68, 95% confidence interval [CI]: 0.54–0.87, p<0.01) was lower than (0.69, CI: 0.54–0.88, p<0.001) also who that only. core pattern prescriptions, which preventing nephritis, “Sheng-Di-Huang” (raw Rehmannia glutinosa Libosch.), “Mu-Dan-Pi” (Paeonia suffruticosa Andr.), “Dan-Shan” (Salvia miltiorrhiza Bge.), “Zhi-Bo-Di-Huang-Wan.”, “Chi-Shao” (Paeoniae lactiflorae Rubra). Conclusion Integrative decreased among Taiwan. Further investigation pharmacological mechanism clinical efficacy are warranted.