Sphingolipid functions in Saccharomyces cerevisiae.
作者： Robert C. Dickson , Robert L. Lester
DOI: 10.1016/S1388-1981(02)00210-X
关键词:
摘要: Recent advances in understanding sphingolipid metabolism and function Saccharomyces cerevisiae have moved the field from an embryonic, descriptive phase to one more focused on molecular mechanisms. One advance that has aided many experiments been uncovering of genes for biosynthesis breakdown sphingolipids. S. seems verge becoming first organism which all metabolic are identified. Other include demonstration cells lipid rafts composed sphingolipids ergosterol specific proteins associate with rafts. Roles phytosphingosine (PHS) dihydrosphingosine (DHS) heat stress continue be uncovered including regulation transient cell cycle arrest, control putative signaling pathways govern integrity, endocytosis, movement cortical actin cytoskeleton protein plasma membrane. studies suggest roles exocytosis, growth longevity. Finally, some progress made how synthesis is regulated levels maintained.
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