The role of HLA matching in transplantation.

摘要: All viable human tissues transplanted from one individual to another are at risk of rejection. The extent depends on the donor HLA-host T cell receptor disparity. Such disparity is now known involve genetic products coded by both HLA and non-HLA genes. responses mismatches transplants graded: greater mismatch number clones cells responding. Consequently, more severe rejection process. Global statistics support this view in that cumulative associated with poorer graft survival. However such studies also suggest different loci vary potency. strength seems increase HLA-A, weakest, through HLA-B HLA-DR, most potent. Analysis clinical results suggests kidney transplantation dwindles after first five months post-transplant. Although losses tend occur sporadically thereafter, no major can be discerned. Whether dwindling impact time post-transplant a general phenomenon applicable all transplants, or whether it some form adaptation host transplant recipients alone subject for further exploration. Tissues widely their susceptibility mismatches.(ABSTRACT TRUNCATED AT 250 WORDS)