Treatment of sperm autoimmunity in men.

摘要: Positive sperm immobilization tests were found in the sera of 6.3% 491 infertile men. There was a higher frequency family histories autoimmune diseases than for other subfertile Prognosis fertility related to results sperm-mucus penetration tests: progressively motile indicated fair outlook--8 15 couples conceived within 7 months either spontaneously or with artificial insemination husband's semen. Absence severe infertility - only 6 72 produced pregnancies. Treatment latter group by temporary suppression spermatogenesis testosterone Artificial Insemination Husband (AIH) appeared be ineffective. However, titres fell and concentrations, motility mucus increased during treatment 14 men prednisolone (0.5-0.75 mg/kg per day) 4-7 there three It is concluded that autoimmunity causing failure penetrate cervical produces but not absolute infertility. Immunosuppression continuous high dose glucocorticoid reduces antibody levels improves semen quality. A controlled trial needed determine if this practical method improving autoimmunity.