Genes specifically expressed at growth arrest of mammalian cells.
作者： Claudio Schneider , Robert M. King , Lennart Philipson
DOI: 10.1016/S0092-8674(88)91065-3
关键词:
摘要: A subtraction cDNA library enriched for RNA sequences preferentially expressed in growth-arrested cells was prepared. Six clones were identified, varying abundance from 2% to 0.0002% of the and size 0.8 10 kb. The corresponding mRNAs are downregulated with different kinetics upon induction growth by serum. after serum starvation density-dependent inhibition two these growth-arrest-specific (gas) genes investigated more detail. Two cell lines transformed viral onc did not express gas genes. full-length one gene has been sequenced protein product preliminarily characterized vitro translation.
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