Peroxisomal participation in psychosine-mediated toxicity : Implications for krabbe's disease
作者： Mushfiquddin Khan , Ehtishamul Haq , Shailendra Giri , Inderjit Singh , Avtar K. Singh
DOI: 10.1002/JNR.20529
关键词:
摘要: Psychosine (galactosylsphingosine) accumulation in globoid cell leukodystrophy (Krabbe's disease) results the loss of myelin and oligodendrocytes. To understand role psychosine toxicity Krabbe's disease, we examined effects on peroxisomal functions their relationship with reactive oxygen species. Rat C(6) glial cells were treated without cytokines. Peroxisomal beta-oxidation was significantly inhibited very long chain fatty acid levels free radicals increased cells. Furthermore, treatment decreased glutathione ATP levels, plasmalogen content, expression alkyl-DHAP synthase. Brain tissue twitcher mice (animal model Krabbe's) had activity, low glutathione, reduced plasmalogens. rat primary oligodendrocytes activities. Psychosine-mediated function radical production antioxidant N-acetylcysteine Our suggest that inhibition by may be partly responsible for oligodendrocyte observed brain, therapy useful disease.
sci-hub.se 参考文章(58)
Maurice M. Rapport, Reflections on the great plasmalogen puzzle: effector mediated signal transduction coupled to glyceride structures. Neurochemical Research. ,vol. 23, pp. 273- 275 ,(1998) , 10.1023/A:1022441029834
Inderjit Singh, Oscar Carillo, Aryan Namboodiri, Isolation and biochemical characterization of peroxisomes from cultured rat glial cells. Neurochemical Research. ,vol. 25, pp. 197- 203 ,(2000) , 10.1023/A:1007563201595
Shelley Bhattacharya, Mechanisms of Signal Transduction In The Stress Response of Hepatocytes International Review of Cytology. ,vol. 184, pp. 109- 156 ,(1998) , 10.1016/S0074-7696(08)62180-4
Kunihiko Suzuki, Twenty five years of the "psychosine hypothesis": a personal perspective of its history and present status. Neurochemical Research. ,vol. 23, pp. 251- 259 ,(1998) , 10.1023/A:1022436928925
F. Fonnum, E. A. Lock, The contributions of excitotoxicity, glutathione depletion and DNA repair in chemically induced injury to neurones: exemplified with toxic effects on cerebellar granule cells. Journal of Neurochemistry. ,vol. 88, pp. 513- 531 ,(2003) , 10.1046/J.1471-4159.2003.02211.X
Inderjit Singh, Biochemistry of peroxisomes in health and disease. Molecular and Cellular Biochemistry. ,vol. 167, pp. 1- 29 ,(1997) , 10.1023/A:1006883229684
Ehtishamul Haq, Shailendra Giri, Inderjit Singh, Avtar K. Singh, Molecular mechanism of psychosine‐induced cell death in human oligodendrocyte cell line Journal of Neurochemistry. ,vol. 86, pp. 1428- 1440 ,(2003) , 10.1046/J.1471-4159.2003.01941.X
C E Cooper, M Markus, S P Seetulsingh, J M Wrigglesworth, Kinetics of inhibition of purified and mitochondrial cytochrome c oxidase by psychosine (beta-galactosylsphingosine). Biochemical Journal. ,vol. 290, pp. 139- 144 ,(1993) , 10.1042/BJ2900139
Inderjit Singh, [31] Peroxisomal fatty acid oxidation and cellular redox Methods in Enzymology. ,vol. 352, pp. 361- 372 ,(2002) , 10.1016/S0076-6879(02)52033-4
Makiko Saito, Yuichi Iimori, Shigehiko Kamoshita, Masayoshi Yanagisawa, Yoichi Sakakihara, Effects of peroxisomal β-oxidation antagonist on 2′,3′-cyclic-nucleotide 3′-phosphohydrolase, membrane lipid compositions, and membrane fluidity in C-6 glial cells Biochimica et Biophysica Acta. ,vol. 1235, pp. 178- 182 ,(1995) , 10.1016/0005-2736(95)80003-X