Secular trends in the incidence and timing of surgical intervention for congenital undescended testis and surgically treated hypospadias in Ontario, Canada between 1997 and 2007.

摘要: Summary Introduction Recent studies have suggested contradictory trends in the incidence of undescended testis (UDT) and hypospadias (HYP), partly because methodological issues ascertainment bias. The recently described association “testicular dysgenesis syndrome” links concomitant UDT HYP, with decreasing sperm counts testicular cancer. Current guidelines suggest that orchidopexy for should be performed by 18 months age. Objective We conducted a retrospective population-based cohort study to estimate UDT, HYP Ontario, based on surgical procedure 5 years after birth. hypothesized are stable province Canada, over an 11-year time period. Study design Linked administrative databases held at Institute Clinical Evaluative Sciences (ICES) were used identify all live male newborns between 1997 2007. Incidence rates calculated identifying these anomalies, within analyzed using Cochrane Armitage test trend. Age surgery intervention or repair was determined. Results defined birth, has remained Canada (8.2/1000 births, p-value trend 0.9, 95% CI 8.0–8.4). similarly (3.8/1000 0.8, 3.7–3.9). showed significant increase period (0.2/1000 0.03, 0.2–0.3). median age (23 months, IQR 16–34 months) beyond guideline recommendations, earlier recent years. 17 (IQR 12–26 months). Discussion variable can explained variations methodology differing data sources utilized. current uses minimize information bias correctly index cases HYP. Conclusions hypospadias, Ontario 2007 ( Table ). Concomitant this Most boys undergo . testis, birth 1997–2007. Year Total number births undergoing (per 1000 births) 62,863 8.3 3.6 0.2 1998 61,871 8.0 4.0 1999 61,521 8.4 4.1 2000 60,608 3.8 0.1 2001 62,561 8.2 2002 63,602 7.5 3.9 2003 65,941 8.6 4.2 0.3 2004 66,477 2005 67,101 8.1 3.7 2006 67,966 69,457 8.5 709,968