α-Tocopherol supplementation reduces biomarkers of oxidative stress in children with Down syndrome: a randomized controlled trial.

摘要: Down syndrome (DS) is the most common human chromosomal abnormality. It characterized by mental retardation and several metabolic disturbances, including elevated oxidative stress, which may be causally linked. Treatment with dietary antioxidants has been suggested as a potential method to alleviate damage of DS patients, but prior supplementation work equivocal. To evaluate effects α-tocopherol α-lipoic acid (ALA) on stress biomarkers in children. Ninety-three children aged 7–15 years from both sexes were randomly allocated three groups: (400 IU/day), ALA (100 mg/day) placebo. The intervention period was 4 months. A healthy control group consisted 26 non-DS siblings. Serum thiobarbituric reactive substances (TBARS) urinary 8-hydroxy-2′-deoxyguanosine (8OHdG) used stress. had greater levels baseline than their Moreover, males 8OHdG females (P<0.001) there no significant association between age TBARS did not change significantly over time, or relative Although concentrations decreased ALA, groups compared (P<0.001), mean final differed only placebo (P<0.01). α-Tocopherol diets attenuate at DNA level.