Mast cells and tumour angiogenesis: New insight from experimental carcinogenesis

作者: Enrico Crivellato , Beatrice Nico , Domenico Ribatti

DOI: 10.1016/J.CANLET.2008.03.031

关键词:

摘要: Histopathologic examination and clinical observations of solid haematological malignancies indicates mast cells as key host in the tumour infiltrate, with important consequence on tumour-associated angiogenesis growth. Data suggest indeed that tumour-infiltrating may exert a prominent function angiogenic "switch", which is essential for progression early tumours. The experimental approach has substantially increased our understanding role process accompanies development. This review will focus crucial contribution promoting neovascularization it emerges from most recent carcinogenesis vivo vitro models.

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