Pharmacokinetics of Sulbactam/Ampicillin in Humans: A Review

摘要: Abstract The parenteral kinetics of sulbactam, a potent synergist with ampicillin against broad range clinically important organisms in humans, are similar to those ampicillin. were not affected by co-administration and high levels both agents attained: 15-min infusions 2 g plus 1 sulbactam produced peak serum concentrations approximately 120 micrograms ampicillin/ml 60 sulbactam/ml; intramuscular injections 0.5 18 13 sulbactam/ml. drugs had half-lives (approximately hr), excreted primarily the urine (greater than 75%). Although postpartem women surgical patients young men, half-life (like that ampicillin) was altered elderly, during labor, neonates, renal impairment. After distribution body, blister fluid serum. Furthermore, useful antibacterial found pus, sputum, middle-ear fluid. normally low penetration into cerebrospinal increased bacterial meningitis.