Possible involvement of DNA strand breaks in regulation of cell differentiation.
作者： N Sjakste , T Sjakste
DOI: 10.4081/1129
关键词:
摘要: The present review summarizes data on the accumulation of DNA strand breaks in differentiating cells. Large 50 Kbp free fragments were observed by several research teams non-apoptotic insect, mammal and plant A more intensive breakage was during maturation spermatides, embryo development, differentiation myotubes, epidermal cells, lymphocytes neutrophils. In general, cells cannot be attributed to decrease repair efficiency. Poly(ADP)ribose synthesis often follows We hypothesize that fragmentation is an epigenetic tool for regulation process. Scarce localization differentiation-associated indicate their preferred specific sequences including nuclear matrix attachment sites repeats. Recent functions caspases provide evidence possible existence a mechanism resembling initial stage apoptosis. Excision methylated cytosine recombination are other explanations phenomenon. Elucidation mechanisms differentiation-induced appears possess considerable potential.
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