Substance K : A novel mammalian tachykinin that differs from substance P in its pharmacological profile

作者: Hiroyuki Nawa , Masami Doteuchi , Ken'ichi Igano , Ken Inouye , Shigetada Nakanishi

DOI: 10.1016/0024-3205(84)90087-0

关键词:

摘要: Abstract The primary structure of one the bovine brain substance P precursors has shown existence a second mammalian tachykinin sequence, named K, that is remarkable homologous to amphibian peptide kassinin. In this study, three K sequences were chemically synthesized and submitted parallel bioassays with kassinin, physalaemin. results show peptides all possess biological activities characteristic family their more closely resemble those kassinin than or This suggests may have physiological role which related but different from in organisms.

参考文章(13)
G. Falconieri Erspamer, V. Erspamer, D. Piccinelli, Parallel bioassay of physalaemin and kassinin, a tachykinin dodecapeptide from the skin of the African frog Kassina senegalensis. Naunyn-schmiedebergs Archives of Pharmacology. ,vol. 311, pp. 61- 65 ,(1980) , 10.1007/BF00500303
Chi-Ming Lee, Leslie L. Iversen, Michael R. Hanley, Bengt E. B. Sandberg, The possible existence of multiple receptors for substance P. Naunyn-schmiedebergs Archives of Pharmacology. ,vol. 318, pp. 281- 287 ,(1982) , 10.1007/BF00501166
Ken’ichi Igano, Yuriko Minotani, Nobuo Yoshida, Masao Kono, Ken Inouye, A Synthesis of Human Proinsulin C-Peptide Bulletin of the Chemical Society of Japan. ,vol. 54, pp. 3088- 3094 ,(1981) , 10.1246/BCSJ.54.3088
G. Falconieri Erspamer, L. Negri, D. Piccinelli, The use of preparations of urinary bladder smooth muscle for bioassay of and discrimination between polypeptides Naunyn-Schmiedeberg's Archives of Pharmacology. ,vol. 279, pp. 61- 74 ,(1973) , 10.1007/BF00502068
Giuseppe de Caro, Maurizio Massi, Luigi G. Micossi, Modifications of drinking behaviour and of arterial blood pressure induced by tachykinins in rats and pigeons. Psychopharmacology. ,vol. 68, pp. 243- 247 ,(1980) , 10.1007/BF00428110
A. F. Bradbury, M. D. A. Finnie, D. G. Smyth, Mechanism of C-terminal amide formation by pituitary enzymes Nature. ,vol. 298, pp. 686- 688 ,(1982) , 10.1038/298686A0
Kenji Kangawa, Naoto Minamino, Naoyoshi Chino, Shumpei Sakakibara, Hisayuki Matsuo, The complete amino acid sequence of α-neo-endorphin Biochemical and Biophysical Research Communications. ,vol. 99, pp. 871- 878 ,(1981) , 10.1016/0006-291X(81)91244-4
P. G. Pietta, Garland R. Marshall, Amide protection and amide supports in solid-phase peptide synthesis Journal of the Chemical Society D: Chemical Communications. pp. 650- 651 ,(1970) , 10.1039/C29700000650
Donald F. Steiner, Paul S. Quinn, Shu Jin Chan, Jon Marsh, Howard S. Tager, PROCESSING MECHANISMS IN THE BIOSYNTHESIS OF PROTEINS Annals of the New York Academy of Sciences. ,vol. 343, pp. 1- 16 ,(1980) , 10.1111/J.1749-6632.1980.TB47238.X
T. M. Jessell, Substance P in the Nervous System Springer, Boston, MA. pp. 1- 105 ,(1983) , 10.1007/978-1-4613-3515-3_1