Estrogen administration increases neuronal responses to excitatory amino acids as a long-term effect.

摘要: Abstract Ongoing studies from this laboratory have demonstrated marked potentiating actions of the sex steroid 17β-estradiol (E2) on glutamate-induced excitation. In present study, systemic injection a physiological dose fo E2 was to augment significantly excitatory responses cerebellar Purkinje (Pnj) cells iontophoretic application specific amino acid (e.a.a.) agonists quisqualate and N- methyl- d -aspartate . Potentiation e.a.a. observed as rapidly 5–10 min post E2, was, in many cases, persistent, non-decremental effect. These long-term may provide one mechanism for activating effects sensorimotor function acitivity.