Clinical and bacteriological aspects on the use of oxytetracycline and flunixin in primiparous cows with induced retained placenta and post-partal endometritis.

摘要: Retention of the fetal membranes and post-partal endometritis (RFM) are common problems in dairy cows. Treatment often includes manual removal placenta combination with antibiotic treatment. Earlier studies have shown that cows post-partum a strong tendency to recover spontaneously. The present study focused on treatments prostaglandin synthesis inhibitor, flunixin (F) either alone or combined oxytetracycline (T). was conducted two experiments, using 12 primiparous each. As model for RFM, premature parturition induced late pregnant heifers by injecting PGF2alpha (25 mg i.m.) twice 24 h interval. In each experiment were set into four groups treated T (10 mg/kg BW i.m. once daily), F (2.2 p.o. (dosage, as above) conservatively (group 0, no drugs). treatment periods lasted from days 11-14 I (groups T1, F1, TF1 0) 3-6 2 T2, F2, TF2 0). Jugular vein blood samples collected analyses total white cells. Uterine biopsies weekly investigation endometrial microbiology. Rectal palpation ultrasonographic examinations performed three times investigations uterine involution ovarian activity. No attempts made remove placentas manually. until day 56 post-partum. induction successful all 22 animals had RFM. All RFM bacterial endometritis. predominant bacteria Escherichia coli alpha-haemolytic streptococci, Fusobacterium necrophorum, Arcanobacterium (Actinomyces) pyogenes, Bacteroides spp., Pasteurella spp. Proteus necrophorum A. pyogenes could be isolated 3-5 weeks E. 2-3 Animals tetracycline after placental shedding (T1 TF1) more rapid recovery infections F. than not tetracycline. other genera affected. Antibiotic before (T2 TF2) did shorten infection but altered flora, seen an overgrowth (p < 0.05) increased frequency 0.05). streptococci less T2 (NS). TF2, n = 6) postponed detachment compared antibiotics administered (T1, TF1, F2 16. 9.8 pp (median) versus p 0.004). Neither shortened involution. Flunixin seem influence It concluded early retained cow it slow down process placenta. Oxytetracycline might otherwise affect clinical results. outcome disease.