On glucose diffusivity of tissue engineering membranes and scaffolds

摘要: Abstract There has been an increasing interest in the concept of growing artificial tissues bioreactors which use numerous membranes and scaffolds to support cellular processes such as cell growth nutrient uptake. While these approaches are promising may be considered successful some circumstances, there is a general lack quantitative information on glucose (nutrient) diffusivity materials. In addressing this issue we have carried out series well-defined laboratory experiments measure diffusion coefficient across number tissue engineering saturated with water culture medium (CCM). For purpose, was constructed five different varying pore size shapes were employed, include cellulose nitrate membrane, polyvinylidene fluoride poly( l -lactide) scaffold, poly(caprolactone) scaffold collagen scaffold. Pore distribution, porosity tortuosity materials then determined correlated values. As expected, found that increases These relationships non-linear non-monotonic nature they depend factors basic building blocks non-periodic heterogeneous vary within same material, or from one material another. We observed diffusivities CCM significantly reduced at given temperature contrary what generally assumed previous studies transport processes. Therefore, conclusion can drawn presence extra components difference fluid properties compared significant effect scaffolds.